In my case, having absolutely no sense of direction, the more grid-like an area is, the easier for me to get lost, because all the streets look the same and I never have an idea in which direction I’m going. Just yesterday, walking home, I spent a quarter of an hour walking north when I thought I was going east. In an area of the city I walk through very often.
Sometimes I can compensate by remembering the street names… but I’m also very bad with names. Even worse, similar names -or names that my brain sees as related- can totally blend with each other. For instance, near my home are two long and wide streets, parallel, but at some distance from each other, one named after a prince and another after a count. To mt brain, since both streets are “nobility title + of + place name” both are exactly the same street, and there is no way to convince him otherwise.