We saw Duplicate Lottie in the same frame as Lottie, when Lottie first arrived at the Slag Pit. She’s on the right hand side, wearing a skeleton costume. Of course, knowing John’s more metaphorical drawing style, that doesn’t necessarily mean she was physically present, but, given that the evidence seems to suggest that Duplicate Lottie murdered Miyamoto, I really don’t see John making Lottie a murderer. Framing her for murder, yes, but actually making her a murderer? I don’t think so.